Pharmaceutical Toxicology Testing – MB Research Labs

Pharmaceutical Toxicology Testing
Pharmaceutical Toxicology Testing

Your Trusted Toxicology Testing Partner

We have the Experience.

Since 1972, MB Research Labs is a GLP contract research organization (CRO) that has been performing toxicology (acute, subchronic / chronic) and pharmacology studies for leaders in the pharmaceutical, biotechnology, medical device and agrochemical industries and government agencies.
With a wide range of testing protocols available, MB Research Labs offers comprehensive capabilities to to address your unique needs and goals with speed and accuracy.
Our expertise in many areas of in vivo and in vitro testing, research, and safety evaluations is the foundation upon how MB Research serves the pharmaceutical toxicology testing needs of both government and industry.

Complete support services including consultation, protocol development, quality assurance, analytical chemistry and archive facilities are integral components of studies performed at MB.
Our technical and support procedures are in full compliance with OECD, FDA, and EPA.

Related Toxicology Testing

EPA-OCSPP Testing

  • MB offers GLP Toxicology Testing for pesticides and chemicals.
  • Extensive list of Protocols Available
  • Discount Pricing

Photo-Toxicology

  • In Vitro 3T3 Neutral Red Uptake Phototoxicity Test
  • Monolayer & 3D Tissue Models
  • OECD 432 protocol

In Vitro Toxicology

  • Your Source for In Vitro & Alternatives to Animal Testing.
  • Cost Saving Screening Testing
  • Cosmetics & Personal Care Testing

MB Research Labs is a leader in the use and development of
in vitro and alternative toxicology test methods. We specialize in protocols for Eye and Skin Irritation, Corrosivity, Skin Sensitization, Genotoxicity, and Phototoxicity.

For more info about MB Research.

Chemical Toxicology Testing for Geeks

We Love Chemistry, How About You?

Chemical Toxicology Testing
Chemical Toxicology Testing

Chemical Toxicology Testing Overview

  • Over 45 Yrs Experience. MB Research Labs has been a primary provider of chemical safety testing services to the chemical and consumer products industries.
  • MB Research has been accredited by AAALAC International, a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs since 1975.
  • Over 50,000 toxicigical studies performed – Extensive expertise in conducting in vivo toxicology
  • Standardized GLP Protocols available for skin and eye irritation, oral and dermal toxicity, dermal sensitization assays and phototoxicity.

Toxicology Testing Experience You Are Looking For.

With a wide range of in vivo and in vitro test protocols available, MB Research Labs offers comprehensive capabilities to address your unique needs and goals.

MB has decades of expertise in many areas of in vivo and in vitro
testing, research, and safety evaluations, MB Research serves the testing needs of both government and industry.  Our complete support services including consultation, protocol development, quality assurance, analytical chemistry and archive facilities are integral components of studies performed at MB.  Our technical and support procedures are in full compliance with OECD, FDA, and EPA.

Chemical toxicology studies are routinely performed on a wide variety of compounds. The selection of specific studies to be conducted is based on the intended use of the compound and the applicable regulatory requirements. Protocols for the most commonly implemented regulatory studies are available upon request.

Related Links

Phototoxicity Testing Services – 3T3 NRU PT

Phototoxicity / Phototoxicology Testing

3T3 NRU PT phototoxicity
3T3 NRU PT phototoxicity

MB Research Labs is a leading in vitro toxicology laboratory that offers toxicological testing services to the cosmetic, chemical and pharmaceutical industries.

One of the more important assays offered in the 3T3 Neutral Red Uptake Phototoxicity (3T3 NRU PT) Assay. The 3T3NRUPT is used to screen test materials for the potential of causing photoirritation after exposure to the material and sunlight.

The 3T3 NRU PT was developed and validated in a joint EU/COLIPA project from 1992-1997. In 1996, the 3T3 NRU PT was recommended by OECD as an in vitro approach for the assessment of chemicals phototoxicity potential. In April 2004, the 3T3 NRU PT protocol was finalized and adopted as the OECD 432 protocol, In Vitro 3T3 NRU phototoxicity test.

The 3T3 NRU PT can be utilized to identify the phototoxic effect of a test substance induced by the combination of test substance and light and is based on the comparison of the cytotoxic effect of a test substance when tested after the exposure and in the absence of exposure to a non-cytotoxic dose of UVA/vis light. Cytotoxicity is expressed as a concentration-dependent reduction of the uptake of the vital dye – Neutral Red.

Substances that are phototoxic in vivo after systemic application and distribution to the skin, as well as compounds that could act as phototoxicants after topical application to the skin can be identified by the test. The reliability and relevance of the 3T3 NRU PT have been evaluated and has been shown to be predictive when compared with acute phototoxicity effects in vivo in animals and humans.

For more information about the 3T3 NRU PT and MB Research Labs….

US TSCA Changes Impact Animal Use in Chemical Testing

Changes in TSCA Reduces Use of Animals

https://www.washingtonpost.com/news/animalia/wp/2016/06/08/a-big-victory-for-lab-rats-congress-moves-to-limit-chemical-testing-on-animals/

As Regulators begin to initiate laws and regulations that require the reduction of using live animals for safety studies, more and more companies are looking for valid substitutes that are economical and thorough.

In Vitro Toxicology Testing

Let MB Research help in that search, In Vitro Toxicology Testing Services.

Since the late 1980s, MB Research has been a pioneer in the used and development of in vitro & alternative test methods, reducing the use of live animals in toxicological research.

What are the 3 Rs?

The principle of the 3Rs was first mentioned by William Russell and Rex Burch in 1959. In their book “The Principles of Humane Experimental Technique”, they classified humane techniques under the headings Refinement, Reduction, and Replacement, commonly known now as the 3Rs.

MB Research Laboratories prides itself on pursuing in vitro and alternative toxicological methods that Reduce, Refine and Replace the use of animals in laboratory research and has worked with many leaders in this field to advance the development, validation and regulatory acceptance of in vitro and alternative tests with a goal on replacing laboratory animals in toxicological research.

MB Research presents at Pan-American Conference for Alternative Methods

Pan-American Conference for Alternative Methods (PACAM), April 12-14, 2016, hosted by Johns Hopkins University

MB Research Labs will be attending the PACAM conference. The PACAM brings together experts and stakeholders from across the Americas, with a focus on the Six Rs: Replacement, Reduction, Refinement, Read-across, Relevance, and Roadmaps.

MB Research Labs is serving on the organizing committee. MB Research Chief Scientific Officer, Dr. George DeGeorge and Director of Toxicology, Bennett Varsho, will be presenting informative talks on in vitro toxicology methods: the In Vitro Sensitization Assay (IVSA) and the Human Cell Line Activation Test (h-CLAT) as well as presenting scientific posters.

Please click for more PACAM information!

For more information about In Vitro Toxicology Testing.

Consumer Product Safety Testing and National Poison Prevention Week

Consumer Product Safety Testing

Consumer Products Safety Testing
Consumer Products Safety Testing

With it being National Poison Prevention Week, it seems a great time to highlight some testing areas that MB Research Labs specializes in – Consumer Product Safety Testing.
National Poison Prevention Week – Consumer Product Safety Commission

MB Research provides an extensive array of testing protocols that will help meet your regulatory requirements to ensure safe use of your products.

Rely on our experience in the classification of your fast moving consumer goods using both in vivo and in vitro testing models.

Health, Home, and Hygiene

  • Liquid and Hand soaps
  • Dishwasher Detergents
  • Disinfectants
  • Biological Extracts
  • Laundry Detergents
  • Household and Industrial Cleansers
  • Surfactants
  • Raw materials

In Vivo Toxicology Testing (CPSC, FDA, EPA, OECD, OCSPP)

  • Acute EPA and OECD Toxicology Testing
  • Dermal Irritation and Contact Sensitization Studies
  • Oral and Inhalation Studies
  • Subchronic & Chronic Toxicology Testing
  • Mucosal Irritation Studies

Subchronic and chronic toxicology studies are conducted at MB Research and are individually designed for the sponsor in order to comply with specific regulatory requirements and intended use of the test substance.  Studies are performed by highly trained and qualified personnel and closely supervised by a Senior Toxicologist at every phase.

Pathological requirements related to studies are under the direction of a Board Certified Veterinary Pathologist.

In Vitro Toxicology Testing