Data from high throughput in vitro tests are being generated for many chemicals of environmental and commercial interest, with the expectation that in vitro assay data could ultimately be used to predict adverse effects of chemical exposures in vivo. Translating values obtained from in vitro assays into estimates of in vivo outcomes is a complex process involving the use of mathematical modeling and increasingly complex test systems. This series of four webinars culminating in an in-person workshop aims to address the capabilities and the limitations of in vitro to in vivo extrapolation (IVIVE) within the context of risk decision making.
From: National Toxicology Program
Registration info here: http://ntp.niehs.nih.gov/pubhealth/evalatm/3rs-meetings/ivive-2016/ivive-2016.html
Free to the Public.
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The 3T3 NRU PT is an in vitro toxicology test used to identify the phototoxic effect of a test substance induced by the combination of test substance and light and is based on the comparison of the cytotoxic effect of a test substance when tested after the exposure and in the absence of exposure to a non-cytotoxic dose of UVA/vis light.