Here is another interesting webinar provided by ICCVAM regarding the use of Quantitative SAR models and Read-Across Techniques that may aid in the development of predictive in vitro toxicology testing methods.
Registration is still open! ICCVAM Communities of Practice Webinar 2016 – Fundamentals of Using Quantitative Structure–Activity Relationship Models and Read-across Techniques in Predictive Toxicology
January 26, 2016 — 1:00-2:30 p.m. Eastern Standard Time
Many commercial and environmental chemicals lack toxicity data necessary for users and risk assessors to make informed decisions about their potential health effects. Computational methods use data about structure, properties, and toxicity from tested chemicals to make predictions about the characteristics of untested chemicals. These include quantitative structure–activity relationship models, which predict the activities of chemicals with unknown properties by relating them to properties of known chemicals, and read-across, which uses toxicity data from a known (source) chemical to predict toxicity for another (target) chemical, usually but not always on the basis of structural similarity. Predictions made using these methods about toxicity of untested chemicals can help set priorities for future in vitro or in vivo testing, ensuring that the most important hazards are characterized first and that testing resources are used efficiently.
“Do not go where the path may lead, go instead where there is no path and leave a trail.”
Ralph Waldo Emerson
In Vitro Toxicology Testing
In Vitro Toxicology Testing is more widely accepted than before. More in vitro and alternative testing methods are being validated and accepted by regulatory agencies at an increasingly faster pace. Technology is rapidly advancing new approaches to replacing the use of animals in toxicological studies.
MB Research Labs is a pioneer in the use and development of in vitro toxicology testing. Our scientists have been working diligently on developing new in vitro test methods such as, 3D human tissue constructs, co-culture systems, and kinetic tissue culture methods.
MB Research Labs may be able to help there too. With over 40 years of Acute Toxicology Testing experience, MB Research has standard protocols that meet pre-clinical testing requirements for EPA, FDA, OECD, GHS and other guidelines. More…
Corrositex® is an in vitro method used to determine the dermal corrosive potential of chemicals and chemical mixtures. Corrositex® has been designed as a replacement for the dermal corrosivity rabbit test based upon proprietary bio-membrane and chemical detection technology developed by In Vitro International.
Why Use Corrositex®?
Time Savings: Corrositex® testing can provide a Packing Group determination in a matter of minutes and no more than 4 hours, unlike animal testing which can take 2 – 4 weeks.
Accuracy: More accurate than pH testing and is packing group specific.
Cost Savings: Reduced shipping charges, additional cost savings workplace safety and MSDS development.
Why Should I Have Corrositex Performed at MB?
Unbiased 2nd Party Test Results in a Report Format
Reputable Contract Lab with over 40 years of Regulatory Testing Experience
We worry about the details. Less Hassle and Effort on your part.
Can I get a discount for having multiple products tested?
Absolutely, we offer aggressive discounting for multiple tests performed at the same time.
If my test material doesn’t cause a change in color in the Corrositex® chemical detection fluid, what then?
Chemicals are prescreened for compatibility with Corrositex® by directly applying the test chemical or chemical mixture to the detection fluid; if a color change is not induced, then the test chemical or chemical mixture does not qualify for testing with Corrositex®. Contact MB Research, we can offer you more testing options.
MB Research Labs – Advancing In Vitro/Alternative Test Methods.
Three dimensional human tissue constructs have proven to be very effective screening tools for irritation and corrosivity testing for the cosmetic, petrochemical, and pharmaceutical industries. Tissue constructs have been utilized for many years for ocular and dermal toxicity screening at MB Research Labs
Other tissue types (buccal, brochial, vaginal, dermal, ocular, tanned epidermis) that exhibit in vivo-like morphological and growth characteristics are available from various vendors. MB Research frequently works closely with these manufacturers to develop innovative testing protocols that fit our clients’ needs.
More and more interest in the utility of these 3D tissue models has increased especially since their use reduces the number of animals used in Toxicology testing.
The Direct Peptide Reactivity Assay (DPRA) is an in chemico
method used to predict epidermal protein binding. Binding of epidermal proteins is the molecular initiating event on the AOP.
The DPRA uses HPLC to measure the depletion of synthetic peptides in solution following exposure to test chemicals.
The principle of the 3Rs was first mentioned by William Russell and Rex Burch in 1959. In their book “The Principles of Humane Experimental Technique“, they classified humane techniques under the headings Refinement, Reduction, and Replacement, commonly known now as the 3Rs.
MB Research Laboratories prides itself on pursuing in vitro and alternative toxicological methods that Reduce, Refine and Replace the use of animals in laboratory research and has worked with many leaders in this field to advance the development, validation and regulatory acceptance of in vitro and alternative tests with a goal on replacing laboratory animals in toxicological research.
MB Research is also conducting developmental and validation studies to advance application of in vitro and alternative toxicology tests. More information about currently funded research can be found here.
Data from high throughput in vitro tests are being generated for many chemicals of environmental and commercial interest, with the expectation that in vitro assay data could ultimately be used to predict adverse effects of chemical exposures in vivo. Translating values obtained from in vitro assays into estimates of in vivo outcomes is a complex process involving the use of mathematical modeling and increasingly complex test systems. This series of four webinars culminating in an in-person workshop aims to address the capabilities and the limitations of in vitro to in vivo extrapolation (IVIVE) within the context of risk decision making.
From: National Toxicology Program
Registration info here: http://ntp.niehs.nih.gov/pubhealth/evalatm/3rs-meetings/ivive-2016/ivive-2016.html
Free to the Public.
EXPERIENCE and INNOVATION.
MB Research Labs is uniquely positioned to utilize over 40 years of in vivo toxicology experience and nearly 20 years of innovating In Vitro Toxicology Testing.
Don’t Get Burned when formulating your new product.
The 3T3 NRU PT is an in vitro toxicology test used to identify the phototoxic effect of a test substance induced by the combination of test substance and light and is based on the comparison of the cytotoxic effect of a test substance when tested after the exposure and in the absence of exposure to a non-cytotoxic dose of UVA/vis light.