Advancing Predictive Toxicology Methods using QSAR & Read-Across

Here is another interesting webinar provided by ICCVAM regarding the use of Quantitative SAR models and Read-Across Techniques that may aid in the development of predictive in vitro toxicology testing methods.

Areas of Impact. In Vitro Toxicology Testing.
Areas of Impact. In Vitro Toxicology Testing.

Registration is still open!
ICCVAM Communities of Practice Webinar 2016 – Fundamentals of Using Quantitative Structure–Activity Relationship Models and Read-across Techniques in Predictive Toxicology
January 26, 2016 — 1:00-2:30 p.m. Eastern Standard Time

Many commercial and environmental chemicals lack toxicity data necessary for users and risk assessors to make informed decisions about their potential health effects.  Computational methods use data about structure, properties, and toxicity from tested chemicals to make predictions about the characteristics of untested chemicals.  These include quantitative structure–activity relationship models, which predict the activities of chemicals with unknown properties by relating them to properties of known chemicals, and read-across, which uses toxicity data from a known (source) chemical to predict toxicity for another (target) chemical, usually but not always on the basis of structural similarity.  Predictions made using these methods about toxicity of untested chemicals can help set priorities for future in vitro or in vivo testing, ensuring that the most important hazards are characterized first and that testing resources are used efficiently.

More information regarding In Vitro Toxicology Testing.

Shipping Corrosive Materials?

in vitro Corrosivity testing - in vitro toxicology
in vitro Corrosivity testing – in vitro toxicology

What is Corrositex®?

Corrositex® is an in vitro method used to determine the dermal corrosive potential of chemicals and chemical mixtures. Corrositex® has been designed as a replacement for the dermal corrosivity rabbit test based upon proprietary bio-membrane and chemical detection technology developed by In Vitro International.

Why Use Corrositex®?

time-buttonTime Savings: Corrositex® testing can provide a Packing Group determination in a matter of minutes and no more than 4 hours, unlike animal testing which can take 2 – 4 weeks.


accuracy-buttonAccuracy: More accurate than pH testing and is packing group specific.


saving-costCost Savings: Reduced shipping charges, additional cost savings workplace safety and MSDS development.

FAQs

Why Should I Have Corrositex Performed at MB?

  • Unbiased 2nd Party Test Results in a Report Format
  • Reputable Contract Lab with over 40 years of Regulatory Testing Experience
  • We worry about the details. Less Hassle and Effort on your part.

Can I get a discount for having multiple products tested?

Absolutely, we offer aggressive discounting for multiple tests performed at the same time.

If my test material doesn’t cause a change in color in the Corrositex® chemical detection fluid, what then?

Chemicals are prescreened for compatibility with Corrositex® by directly applying the test chemical or chemical mixture to the detection fluid; if a color change is not induced, then the test chemical or chemical mixture does not qualify for testing with Corrositex®. Contact MB Research, we can offer you more testing options.

For more info about Corrositex Testing, check out www.corrositex.com!

MB Research Labs – Your In Vitro Toxicologist

In Vitro Sensitization – First Steps

Sensitization testing for household and consumer products has traditionally been performed using in vivo study models with guinea pigs and mice.

MB Research now offers an Integrated Testing Strategy (ITS) of in vitro toxicology tests that follows a specific Adverse Outcome Pathway for acute dermal sensitization.

sensitization adverse outcome pathway
Sensitization Adverse Outcome Pathway

For more information about the ITS for Sensitization.

IVSA

The In Vitro Sensitization Assay (IVSA) is a keratinocyte
activation test. IVSA uses an ELISA method to measure IL-18 release from a topically treated reconstructed 3D human
keratinocyte tissue model.

h-CLAT

The Human Cell Line Activation Test (h-CLAT) is a dendritic
cell activation test. The h-CLAT uses flow cytometry to measure CD86 and CD54 expression on treated THP-1 cells in culture.

DPRA

The Direct Peptide Reactivity Assay (DPRA) is an in chemico
method used to predict epidermal protein binding. Binding of epidermal proteins is the molecular initiating event on the AOP.
The DPRA uses HPLC to measure the depletion of synthetic peptides in solution following exposure to test chemicals.

Also see: In Vitro Toxicology Testing