Over 45 Years of Toxicology Testing – Chemicals, Pharmaceuticals, Cosmetics, Household Products, Personal Care Products
MB Research Laboratories, a GLP contract research Toxicology laboratory, has been conducting acute, subchronic / chronic toxicological and pharmacological studies since 1972. MB Research provides industry-leading general toxicology services for the pharmaceutical, biotechnology, medical device and agrochemical industries and government agencies. Routine and non-traditional toxicology studies are performed, custom testing services to meet specific testing needs is available.
Study Directors and technicians strive to consistently deliver exemplary results to support both Good Laboratory Practices(GLP) and non-GLP Toxicology studies. With a wide range of in vivo and in vitro test protocols available, MB Research Labs offers comprehensive Toxicology Testing capabilities to address your unique needs and goals. With expertise in many areas of in vivo and in vitro testing, research, and safety evaluations, MB Research serves the testing needs of both government and industry.
Complete support services including consultation, protocol development, quality assurance, analytical chemistry and archive facilities are integral components of studies performed at MB. Our technical and support procedures are in full compliance with OECD, FDA, and EPA.
As Regulators begin to initiate laws and regulations that require the reduction of using live animals for safety studies, more and more companies are looking for valid substitutes that are economical and thorough.
Since the late 1980s, MB Research has been a pioneer in the used and development of in vitro & alternative test methods, reducing the use of live animals in toxicological research.
What are the 3 Rs?
The principle of the 3Rs was first mentioned by William Russell and Rex Burch in 1959. In their book “The Principles of Humane Experimental Technique”, they classified humane techniques under the headings Refinement, Reduction, and Replacement, commonly known now as the 3Rs.
MB Research Laboratories prides itself on pursuing in vitro and alternative toxicological methods that Reduce, Refine and Replace the use of animals in laboratory research and has worked with many leaders in this field to advance the development, validation and regulatory acceptance of in vitro and alternative tests with a goal on replacing laboratory animals in toxicological research.
Hazardous shipping labels can be complex. There are kits that can be purchased that can satisfy regulatory requirements, but getting a kit alone does not provide they well-being you get when the test is performed by an experienced laboratory with a excellent quality assurance follow up and an acutal report.
Weigh of Evidence (WoE) testing with in vitro test methods is now being accepted by European chemical agencies to satisfy REACH requirements. This is especially helpful when specific regulatory guidelines require complex safety testing but no validated in vitro test or alternative assay exists.
WoE must be accompanied with substantial background data to aid in acceptance of our provided safety data. GLPs are a must.
MB Research Labs offers many in vitro test methods that are directly in-line with some regulatory testing requirements as well as novel in vitro test that have not been accepted yet but can still provide a strong case for safety assessments.
Topical application is the main route of skin toxicity, whether it is an intentional or unintentional exposure. Also, many consumer products and cosmetics are applied directly on the skin.
Skin irritation is the production of reversible damage to the skin following application of a test material for up to 4 hours. Signs of skin irritation are erythema or redness, edema or swelling as a result of the test material penetrating the stratified layers of the epidermis.
Skin corrosion is the production of irreversible damage to the skin following application of a test material for up to 4 hours. Signs are necrosis throughout the epidermis and dermis layers of the skin.
Skin sensitization is the induction of an allergic reaction in response to exposure to a test material.
Phototoxicity is a toxic response from a test material applied to the body which is ether elicited or increased after subsequent exposure to light, or that is induced by skin irradiation after systemic administration of a test material.
MB Research Labs has an extensive capabilities list with in vitro assays targeting this areas of skin toxicity. We are able to utilize 3D tissue cultures and cell culture techniques to assess the safety of your test material for skin toxicity.
The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) is a United States federal law that outlines the basic U.S. pesticide regulation to protect applicators, consumers, and the environment. FIFRA is administered and regulated by the United States Environmental Protection Agency (EPA) and the appropriate state environmental agencies.
MB Research Labs is a GLP Contract Research Laboratory with over 40 years of regulatory toxicology testing experience. With standard and custom protocols, MB Research can assist you with your testing needs for product registration with the EPA. In vivo and In vitro toxicology tests are available.
MB Research provides an extensive array of testing protocols that will help meet your regulatory requirements to ensure safe use of your products.
Rely on our experience in the classification of your fast moving consumer goods using both in vivo and in vitro testing models.
Health, Home, and Hygiene
Liquid and Hand soaps
Household and Industrial Cleansers
In Vivo Toxicology Testing (CPSC, FDA, EPA, OECD, OCSPP)
Acute EPA and OECD Toxicology Testing
Dermal Irritation and Contact Sensitization Studies
Oral and Inhalation Studies
Subchronic & Chronic Toxicology Testing
Mucosal Irritation Studies
Subchronic and chronic toxicology studies are conducted at MB Research and are individually designed for the sponsor in order to comply with specific regulatory requirements and intended use of the test substance. Studies are performed by highly trained and qualified personnel and closely supervised by a Senior Toxicologist at every phase.
Pathological requirements related to studies are under the direction of a Board Certified Veterinary Pathologist.
Got a medical device, implant, etc???? Then you need testing….
In vitro & in vivo biological compatibility/safety evaluations are required by regulations to be conducted for biomaterials, medical devices, and related products to identify potential risks for the use of a device in humans.
Biocompatibility testing ranges from the screening of new materials to product release testing, audit testing, and pre-market safety evaluations to meet current FDA guidance and ISO 10993 standards.